Nav1.8-IN-16

Nav1.8-IN-16 (Compound (R) -40) is an orally active and selective hNaV 1.8 inhibitor (IC50: 5.9 nM) . Nav1.8-IN-16 exerts analgesic effects by blocking NaV1.8 channels without significantly affecting other NaV subtypes or hERG channels. Nav1.8-IN-16 exhibits dose-dependent analgesic effects in postoperative pain and inflammatory pain models and can be used in pain-related research[1].

Product Specifications

UNSPSC

12352005

Target

Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(NC1=CC=C(F)C(C(N)=O)=C1)C2=CC(Cl)=C(C(F)(F)F)C=C2[C@H]3CCOC4=C3C=CC=C4F

Molecular Formula

C24H16ClF5N2O3

Molecular Weight

510.84

References & Citations

[1]Li N, et al. Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties. Eur J Med Chem. 2025 May 6;293:117697.