AMPK activator 17

AMPK activator 17 (Compound 10g) is an orally active AMPK activator. AMPK activator 17 has significant anti-adipogenic (IC50: 3.4 μM) and dyslipidemia-modifying activities. AMPK activator 17 inhibits the early stages of adipocyte differentiation (mitotic clonal expansion) by activating the AMPK pathway. AMPK activator 17 can enhance mitochondrial function and fatty acid oxidation in mature adipocytes. AMPK activator 17 improves dyslipidemia by promoting reverse cholesterol transport. AMPK activator 17 can be used in the study of obesity and related metabolic diseases (such as type 2 diabetes and cardiovascular disease) [1].

Product Specifications

UNSPSC

12352101

Target

AMPK

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

O=C(C1=C(C)NC(NC1C2=CN=CS2)=O)OCC3=CC(C4=CC=C(Cl)C=C4)=NO3

Molecular Formula

C19H15ClN4O4S

Molecular Weight

430.86

References & Citations

[1]Alisha Ansari, et al. Design, synthesis, and biological evaluation of isoxazole-dihydropyrimidinone hybrids as potential modulators of adipogenesis and dyslipidemia. European Journal of Medicinal Chemistry. Volume 294. 2025,117746, ISSN 0223-5234.