Carbonic anhydrase inhibitor 33

Carbonic anhydrase inhibitor 33 (11D) is a dual inhibitor of CA (Carbonic anhydrase) IX/XII and CDK6, with Ki values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Carbonic Anhydrase; CDK

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=S(C1=CC=C(/N=N/C2=C3N=CC=C(C4=CC=C(F)C=C4)N3N=C2C)C=C1)(N)=O

Molecular Formula

C19H15FN6O2S

Molecular Weight

410.42

References & Citations

[1]Mahmoud S Elkotamy, Rationally designed Pyrazolo[1,5-a]pyrimidines as dual inhibitors of CA IX/XII and CDK6: A novel approach for NSCLC treatment. Eur J Med Chem. 2025 May 9:293:117752.