Carbonic anhydrase inhibitor 33
Carbonic anhydrase inhibitor 33 (11D) is a dual inhibitor of CA (Carbonic anhydrase) IX/XII and CDK6, with Ki values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Carbonic Anhydrase; CDK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=S(C1=CC=C(/N=N/C2=C3N=CC=C(C4=CC=C(F)C=C4)N3N=C2C)C=C1)(N)=O
Molecular Formula
C19H15FN6O2S
Molecular Weight
410.42
References & Citations
[1]Mahmoud S Elkotamy, Rationally designed Pyrazolo[1,5-a]pyrimidines as dual inhibitors of CA IX/XII and CDK6: A novel approach for NSCLC treatment. Eur J Med Chem. 2025 May 9:293:117752.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII; CDK6
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