FSP1-IN-1
FSP1-IN-1 (compound 39) is a potent FSP1 inhibitor with an IC50 of 35 nM. FSP1-IN-1 enhances RSL3 (HY-100218A) -induced lipid peroxide accumulation and sensitizes cancer cells to ferroptosis[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=CC=C(C2=NN=C3N2N=C(CN4CCN(C5=CC=C(C(OC)=O)C=C5)CC4)S3)C=C1
Molecular Formula
C23H24N6O3S
Molecular Weight
464.54
References & Citations
[1]Liu W, et al. Design, synthesis and biological evaluation of triazolothiadiazole derivatives as FSP1 inhibitors for sensitizing cancer cells to ferroptosis. Eur J Med Chem. 2025 May 11;293:117737.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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