PI3K-IN-59
PI3K-IN-59 (Compound 3d) is a PI3K inhibitor (IC50: 17.44 μM) . PI3K-IN-59 has significant antiproliferative activity and exhibits potent inhibitory effects on breast cancer 4T1 cells (IC50: 3.70 μM) and colon cancer CT26 cells (IC50: 1.98 μM) as well as human breast cancer cells (IC50: 19.72 μM) . PI3K-IN-59 exerts a dual anti-tumor mechanism by inhibiting PI3Kα enzymatic activity and triggering the Fenton reaction to generate hydroxyl radicals (•OH) . PI3K-IN-59 shows promising anti-4T1 tumor effects and is suitable for synergistic targeting studies in breast and colon cancers[1].
Product Specifications
UNSPSC
12352211
Target
PI3K; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(c1cccc1)OCCCNC2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2.[][Fe][].c5cccc5
Molecular Formula
C25H32FeN6O4
Molecular Weight
536.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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