Apoptosis inducer 37

Apoptosis inducer 37 (Derivative 10) is an apoptosis inducer. Apoptosis inducer 37 exerts anticancer effects by inducing S-G2/M cell cycle arrest and promoting cell apoptosis. Apoptosis inducer 37 has significant inhibitory activity against HCT116, SKOV3 and HepG2 cancer cells (IC50 values are 24.98 μM, 26.15 μM and 23.09 μM, respectively) . Apoptosis inducer 37 has antitumor effects and can be used in ovarian cancer research[1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[H][C@]12CC[C@@]34CC/C([C@@](CC[C@]3([C@@]1(CCC[C@@]2(C(O)=O)C)C)[H])(C4)C)=N\NS(=O)(C5=CC=C(C=C5)Br)=O

Molecular Formula

C27H37BrN2O4S

Molecular Weight

565.56

References & Citations

[1]Ding Y, et al. Synthesis of Isosteviol derivatives as potential anticancer agents, especially for ovarian Cancer: In vitro cytotoxicity, cell cycle arrest, network pharmacology and molecular docking study. Bioorg Med Chem Lett. 2025 Apr 29;124:130261.