Kv7.2/Kv7.3 activator-2
Kv7.2/Kv7.3 activator-2 is a BBB-penetrable Kv7.2/7.3 activator (EC50: 0.25 μM) . Kv7.2/Kv7.3 activator-2 has good photostability. Kv7.2/Kv7.3 activator-2 has potently antiepileptic effects in maximal electroshock (MES) and sc-pentylenetetrazol (sc-PTZ) -induced acute mice seizure models[1].
Product Specifications
UNSPSC
12352100
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC1=CC2=C(C(C)=C1NC(C3CC4CCC3C4)=O)SC=N2
Molecular Formula
C17H20N2OS
Molecular Weight
300.42
References & Citations
[1]Zhang D, et al. Design, synthesis, and structure-activity relationship of 5, 7-dimethylbenzo [d] thiazoles as novel Kv7.2/7.3 activators with antiepileptic effects [J]. European Journal of Medicinal Chemistry, 2025: 117660.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel
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