PI3K-IN-58
PI3K-IN-58 (Compound 17f) is a PI3Kα inhibitor (IC50: 0.039 μM) . PI3K-IN-58 exhibits significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231 and MDA-MB-453 cell lines with IC50s of 3.48 μM, 1.06 μM, 2.21 μM and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression levels of anti-apoptotic proteins Bcl-XL and Bcl-2 and upregulating the expression of anti-apoptosis protein BAX. PI3K-IN-58 can be used in PI3K-targeted cancer research[1].
Product Specifications
CAS Number
[3067572-78-2]
UNSPSC
12352211
Target
Apoptosis; Bcl-2 Family; PI3K
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(NCCO)/C=C/C1=CC2=NC(C3=CC=CC4=C3C=NN4)=NC(N5CCOCC5)=C2S1
Molecular Formula
C22H22N6O3S
Molecular Weight
450.51
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Bcl-xL; PI3Kα
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