TRBP-IN-1

TRBP-IN-1 (Compound 13j) is an orally active TAR RNA binding protein 2 (TRBP) inhibitor (IC50: 12.72 μM) . TRBP-IN-1 has significant anti-hepatocellular carcinoma (HCC) activity and can inhibit the proliferation and metastasis of HCC cells (HCCLM3 cells (IC50: 18.96 μM) ; SK-Hep-1 cells (IC50: 16.45 μM) ) . TRBP-IN-1 regulates miRNA biogenesis and inhibits oncogenic miRNA expression by targeting TRBP. TRBP-IN-1 induces apoptosis and pyroptosis in HCC cells by inhibiting the level of miRNA. TRBP-IN-1 can be used for targeted therapy research of HCC[1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; DNA/RNA Synthesis; MicroRNA; Pyroptosis

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

COC(C1=C(C(OC)=C(C(OC)=C1)OC)C2=CC=C(C=C2)NC(NC3=CC=CC(C(F)(F)F)=C3)=S)=O

Molecular Formula

C25H23F3N2O5S

Molecular Weight

520.52

References & Citations

[1]Zhang R, et al. Structural optimization and pharmacological evaluation of diphenyl amine esters as anti-hepatocellular carcinoma agents by targeting TAR RNA-binding protein 2. Eur J Med Chem. 2025 Jul 5;291:117676.