IKZF2-degrader 1

IKZF2-degrader 1 (Compound 31) is a IKZF2 molecular glue degrader, with an DC50 of 0.5 nM. IKZF2-degrader 1 has minimal CK1α degradation activity relatively (DC50: 210 nM) . IKZF2-degrader 1 can be used for research of IKZF2-dependent cancers[1].

Product Specifications

CAS Number

[2983840-43-1]

UNSPSC

12352211

Target

IKZF Family; Molecular Glues

Related Pathways

Immunology/Inflammation; PROTAC

Field of Research

Cancer

Smiles

CC(C)NC1=NNC2=C(CN3CCCC3)C=C(C4=C(F)C(CN(C5CCC(NC5=O)=O)C6=O)=C6C=C4)N=C21

Molecular Formula

C27H30FN7O3

Molecular Weight

519.57

References & Citations

[1]Zhang X, et al. Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders. Bioorg Med Chem Lett. 2025 May 5;124:130263.