PKM2-IN-10

PKM2-IN-10 (Compound 16) is a PKM2 inhibitor. PKM2-IN-10 inhibits the proliferation of A549 and HCC1833 cell lines with IC50 of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 exhibits antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. PKM2-IN-10 can be used in lung cancer research[1].

Product Specifications

UNSPSC

12352101

Target

Pyruvate Kinase

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

N=C(N(C)C1=CC(F)=CC(C(F)(F)F)=C1)NC2=CC3=C(N=CC=C3)C4=C2C=CC=N4

Molecular Formula

C21H15F4N5

Molecular Weight

413.37

References & Citations

[1]Zhang W, et al. Discovery of N-methylguanidine derivatives as a new type of potent pyruvate kinase M2 inhibitor. Bioorg Med Chem Lett. 2025 May 5;124:130264.