PKM2-IN-10
PKM2-IN-10 (Compound 16) is a PKM2 inhibitor. PKM2-IN-10 inhibits the proliferation of A549 and HCC1833 cell lines with IC50 of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 exhibits antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. PKM2-IN-10 can be used in lung cancer research[1].
Product Specifications
UNSPSC
12352101
Target
Pyruvate Kinase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N=C(N(C)C1=CC(F)=CC(C(F)(F)F)=C1)NC2=CC3=C(N=CC=C3)C4=C2C=CC=N4
Molecular Formula
C21H15F4N5
Molecular Weight
413.37
References & Citations
[1]Zhang W, et al. Discovery of N-methylguanidine derivatives as a new type of potent pyruvate kinase M2 inhibitor. Bioorg Med Chem Lett. 2025 May 5;124:130264.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKM2
Frequently Asked Questions
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