FLY26
FLY26 is a selective partial GluN2B antagonist with an IC50 value of 0.64 μM. FLY26 partially inhibits the GluN2B subunit of NMDA receptors, reduces calcium ion influx and reactive oxygen species (ROS) production and activates the BDNF/TrkB/CREB neuroprotective signaling pathway to alleviate neuronal excitotoxicity and mitochondrial dysfunction. FLY26 is promising for research of neurological deficits caused by cerebral ischemia-reperfusion injury[1].
Product Specifications
UNSPSC
12352005
Target
IGluR; Reactive Oxygen Species (ROS) ; Trk Receptor
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Protein Tyrosine Kinase/RTK
Field of Research
Cardiovascular Disease
Smiles
O=C(OCC)C1=CN(C=C(C2=CC=C(N=CN(CCN(C)C)C3=O)C3=C2)C=C4)C4=N1
Molecular Formula
C22H23N5O3
Molecular Weight
405.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor; TrkB
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