HPK1-IN-58
HPK1-IN-58 (Compound 26) is an inhibitor of HPK1 (IC50: 2.6 nM) and SLP76 (IC50: 20 nM) . HPK1-IN-58 enhances IL-2 secretion and reverses PGE2-induced immunosuppression. HPK1-IN-58 can be used in anti-tumor immunity research[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; MAP4K
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
CNCC1=NC(N2C(C)(C)CCC2)=CC3=C1CN(C4=NC(C5=NN=C6N5C(C7)C7C6)=CC=C4)C3=O
Molecular Formula
C26H30N8O
Molecular Weight
470.57
References & Citations
[1]Yin Y, et al. Design, synthesis, and biological evaluation of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. Bioorg Chem. 2025 May 1;161:108554.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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