TDO-IN-2
TDO-IN-2 (Compound 5c) is an orally active TDO inhibitor (IC50: 1.25 μM) . TDO-IN-2 has antitumor activity in the Hepa1-6 hepatocellular carcinoma allograft mouse model. TDO-IN-2 has synergistic effects with the PD-1/PD-L1 inhibitor BMS-202 (HY-19745) and can be used to study tumor immune tolerance[1].
Product Specifications
UNSPSC
12352211
Target
Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(/C(C#N)=C/C1=CNC2=CC=CC=C12)NC3=CC(OCCO4)=C4C=C3
Molecular Formula
C20H15N3O3
Molecular Weight
345.35
References & Citations
[1]Wang X, et al. Discovery of (E) -2-cyano-N- (2,3-dihydrobenzo[b][1,4] dioxin-6-yl) -3- (1H-indol-3-yl) acrylamide as a novel TDO inhibitor for cancer treatment. Bioorg Chem. 2025 May 5;161:108555.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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