TDO-IN-2

TDO-IN-2 (Compound 5c) is an orally active TDO inhibitor (IC50: 1.25 μM) . TDO-IN-2 has antitumor activity in the Hepa1-6 hepatocellular carcinoma allograft mouse model. TDO-IN-2 has synergistic effects with the PD-1/PD-L1 inhibitor BMS-202 (HY-19745) and can be used to study tumor immune tolerance[1].

Product Specifications

UNSPSC

12352211

Target

Indoleamine 2,3-Dioxygenase (IDO)

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(/C(C#N)=C/C1=CNC2=CC=CC=C12)NC3=CC(OCCO4)=C4C=C3

Molecular Formula

C20H15N3O3

Molecular Weight

345.35

References & Citations

[1]Wang X, et al. Discovery of (E) -2-cyano-N- (2,3-dihydrobenzo[b][1,4] dioxin-6-yl) -3- (1H-indol-3-yl) acrylamide as a novel TDO inhibitor for cancer treatment. Bioorg Chem. 2025 May 5;161:108555.