HDSI-18

HDSI-18 is an orally active HDAC6 selective inhibitor (IC50: 1.6 nM) . HDSI-18 is cytotoxic to K562, MV4-11, MOLM-13, THP-1, and Jurkat cells (IC50: 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively) . HDSI-18 activates Caspase-3, induces mitochondrial depolarization and apoptosis, and has antitumor activity[1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; Caspase; HDAC

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C1C(CCC(NC2=CC=C(C(NO)=O)C=C2)=O)N(CC3=CC=C(C)C=C3)C(N1CC4=CC=CC=C4)=O

Molecular Formula

C28H28N4O5

Molecular Weight

500.55

References & Citations

[1]Chen C, et al. Design, synthesis and evaluation of structural optimization derived HDAC6 isoform-selective inhibitor. Bioorg Chem. 2025 May 6;161:108562.