CDK2-IN-45

CDK2-IN-45 (Compound 8f) is a CDK2 inhibitor (IC50: 0.64 μM) . CDK2-IN-45 inhibits the proliferation of DU-145 and PC-3 cell lines with IC50 of 2.20 μM and 4.17 μM, respectively. CDK2-IN-45 induces G0/G1 cell cycle arrest and apoptosis. CDK2-IN-45 can be used in prostate cancer research[1].

Product Specifications

UNSPSC

12352101

Target

Apoptosis; CDK

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

ClC(C=C1)=CC=C1C2=CC=NC3=C(C(NC4=CC=CC=C4)=NN32)C5=NC6=C(S5)C=CC=C6

Molecular Formula

C25H16ClN5S

Molecular Weight

453.95

References & Citations

[1]Elkotamy MS, et al. Development of Benzothiazole-grafted Pyrazolo[1,5-a]pyrimidines as new CDK2 inhibitors and anti-prostate cancer agents. Bioorg Chem. 2025 May 7;161:108565.