Estrogen receptor antagonist 9

Estrogen receptor antagonist 9 (Compound 5D) is an estrogen receptor antagonist. Estrogen receptor antagonist 9 shows significant cytotoxicity against MCF7 cells with an IC50 value of 8.50 μM. Estrogen receptor antagonist 9 is promising for research of breast cancers[1].

Product Specifications

UNSPSC

12352211

Target

Estrogen Receptor/ERR

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=C(C(C2=CC=C(Cl)C=C2)=O)SC(NC3=CC=CC=C3)=C1C(NC4=CC=CC=C4)=O

Molecular Formula

C25H19ClN2O2S

Molecular Weight

446.95

References & Citations

[1]Huwaimel B, et al. Precise structure manipulation of selective estrogen receptor modulators led to first-in-class thiophene-3-benzamide derivatives as potential ER-antagonists without uterotrophic activity. Bioorg Chem. 2025 Apr 25;161:108512.