Rapavir
Rapavir (JH-B10) is a selective and potent sodium taurocholate cotransporting polypeptide (NTCP) inhibitor with an IC50 value of 1.8 nM for the uptake of taurocholic acid-d4 (TCA-d4) . Rapavir exerts antiviral activity by directly binding to NTCP and blocking the entry of the virus into cells during the HBV infection phase. Rapavir is promising for research of HBV infections[1].
Product Specifications
Product Name Alternative
JH-B10
UNSPSC
12352101
Target
HBV
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(COC1=CC([C@@H](CCC2=CC=C(C(OC)=C2)OC)OC([C@@H]3CCCCN3C4=O)=O)=CC=C1)N(C)CC(N[C@H](C(N([C@H](C(N[C@H](C(N(C)CC/C=C/C(OCC(C)(C4=O)C)=O)=O)CC5=CC=C(C=C5)F)=O)CC6=CC=CC=C6)C)=O)CC7=CC=C(C=C7)O)=O
Molecular Formula
C68H79FN6O15
Molecular Weight
1239.38
References & Citations
[1]He J, et al. Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry. Signal Transduct Target Ther. 2025 Apr 23;10 (1) :130.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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