KL4-219A
KL4-219A is a selective covalent oncogenic transcription factor MYC degrader. KL4-219A potently and durably degrades MYC in cancer cells. KL4-219A binds covalently to MYC at C203, leading to the destabilization of MYC and subsequent proteasome-dependent degradation. KL4-219A is promising for research of cancers driven by MYC overexpression[1].
Product Specifications
UNSPSC
12352005
Target
C-Myc
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.85
Solubility
DMSO : 23.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC=C(C=C1)N2C([C@]3(C4=CC=CC=C42)CN3[S@](C(C)(C)C)=O)=O
Molecular Formula
C20H22N2O3S
Molecular Weight
370.47
References & Citations
[1]Rosen HT, et al. Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC. bioRxiv [Preprint]. 2025 Feb 27:2025.02.24.639755.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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