Carbonic anhydrase inhibitor 32
Carbonic anhydrase inhibitor 32 (compound 5B) is an orally active and selective hCA (Carbonic anhydrase) II/VII inhibitor with the Ki values of 6.3 nM, 10.1 nM and 681 nM for hCA II, hCA VII and hCA I, respectively. Carbonic anhydrase inhibitor 32 shows neuroprotective and anticonvulsant potential by reducing mTOR activation, and raising hippocampus KCC2 levels[1].
Product Specifications
UNSPSC
12352211
Target
Carbonic Anhydrase; mTOR; NKCC
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(C1=C(N(N=N1)C2=CC=C(C=C2)S(N)(=O)=O)C)N/N=C/C3=CC=CC=C3
Molecular Formula
C17H16N6O3S
Molecular Weight
384.41
References & Citations
[1]Zeidan MA, et al. Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors. J Med Chem. 2025 Apr 24;68 (8) :8873-8893.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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