Vancomycin prodrug

Vancomycin prodrug (compound 13c) is a Vancomycin (HY-B0671) prodrug. Vancomycin prodrug shows antibacterial effect with MICs of 0.78 μM, 0.78 μM, 1.56 μM for S. aureus 330041, MRSA USA 300 and MRSA 3390, respectively. Vancomycin prodrug has the ability to quickly bind to Cys-34 residue of plasma. Vancomycin prodrug exhibits a good therapeutic effect on MRSA USA300 infected mice similar to Vancomycin. Vancomycin prodrug, an albumin-binding acid-sensitive prodrug, effectively reduces Vancomycin’s nephrotoxicity while maintaining its efficacy for Gram-positive bacterial infections[1].

Product Specifications

UNSPSC

12352005

Target

Antibiotic; Autophagy; Bacterial

Related Pathways

Anti-infection; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Smiles

CN[C@@H](C(N[C@H]1C(N[C@H](C(N[C@H]2C(N[C@H]3C(N[C@@H]([C@@H](C4=CC(Cl)=C(OC5=CC2=CC(OC6=CC=C([C@H]1O)C=C6Cl)=C5O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O[C@H]8C[C@](/N=C/C9=CC=C(C=C9O)OCC(NCCCCCCN%10C(C=CC%10=O)=O)=O)([C@@H]([C@@H](O8)C)O)C)O)O)CO)C=C4)O)C(N[C@@H](C%11=CC(O)=CC(O)=C%11C%12=C(C=CC3=C%12)O)C(O)=O)=O)=O)=O)=O)CC(N)=O)=O)=O)CC(C)C

Molecular Formula

C85H95Cl2N11O29

Molecular Weight

1805.63

References & Citations

[1]Tao Li, et al. Targeted vancomycin delivery via in situ albumin conjugation and acid-triggered drug release for reduced nephrotoxicity. Eur J Med Chem. 2025 Jul 5:291:117652.