Succinate dehydrogenase-IN-8

Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L) [1].

Product Specifications

CAS Number

[3030753-68-2]

UNSPSC

12352005

Target

Fungal; Succinate Dehydrogenase

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(C1=CN(C)N=C1C(F)F)NC2(C(NNC3=CC=C(Cl)C(Cl)=C3)=O)CC4=C(C=CC=C4)C2

Molecular Formula

C22H19Cl2F2N5O2

Molecular Weight

494.32

References & Citations

[1]Letian Zhang, et al. Design, Synthesis, and Bioactivity Evaluation of Novel Indene Amino Acid Derivatives as Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2025 Apr 30;73 (17) :10130-10143.