LSD1-IN-42
LSD1-IN-42 (Compound 7ae) is an orally active LSD1 inhibitor that potently inhibits LSD1 activity (IC50 = 0.08 μM) . LSD1-IN-42 downregulates PD-L1 expression and enhances T cell-mediated tumor killing effects. LSD1-IN-42 demonstrates significant anti-gastric cancer activity by inhibiting tumor cell invasion and migration[1].
Product Specifications
UNSPSC
12352101
Target
Histone Demethylase; PD-1/PD-L1
Related Pathways
Epigenetics; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1OCC(C1=C)C(O)C2=CN(C3=C2C=C(C=C3)Cl)S(=O)(C4=CC=C(C([N+]([O-])=O)=C4)N(C)C)=O
Molecular Formula
C22H20ClN3O7S
Molecular Weight
505.93
References & Citations
[1]Zhang H, et al. The Exploration of Indole-Based LSD1-Targeted Inhibitors for Enhanced Immune Response in Gastric Cancer via the PD-L1/PD-1 Axis. J Med Chem. 2025 Apr 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1
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