P38α-IN-9
P38α-IN-9 (Compound 2015) is a p38α inhibitor and blocks p38α’s enzymatic activity with an IC50 lower than 20 nM. p38α-IN-9 inhibits MK2T334 phosphorylation. p38α-IN-9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38α-IN-9 Inhibits colorectal cancer (CRC) metastasis[1].
Product Specifications
CAS Number
2133007-20-0
UNSPSC
12352211
Target
CDK; MAPKAPK2 (MK2) ; p38 MAPK; Wee1
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CNC(C1=CC=C2C(C(C(C=CC(NC3=CC=C(F)C(NC(C4CC4)=O)=C3)=C5)=C5CC2)=O)=C1)=O
Molecular Formula
C27H24FN3O3
Molecular Weight
457.50
References & Citations
[1]Rudalska R, et al. First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer. Nat Cancer. 2025 Feb;6 (2) :259-277.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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