PARP14 inhibitor 1
PARP14 inhibitor 1 (compound Q22) is a selective PARP14 inhibitor with an IC50 of 5.52 nM. PARP14 inhibitor 1 also exhibits anti-inflammatory effects and a half life of 182 min in mouse liver microsomes. PARP14 inhibitor 1 can be utilized in atopic dermatitis research[1].
Product Specifications
CAS Number
[3035493-13-8]
UNSPSC
12352101
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Inflammation/Immunology
Smiles
O=C1NC(N2CC3(C2)CCN(CC3)C(C4CC4)=O)=NC5=CC(OCC6CC6)=CC(F)=C51
Molecular Formula
C23H27FN4O3
Molecular Weight
426.48
References & Citations
[1]Wu S, et al. Discovery and Optimization of Potent and Highly Selective PARP14 Inhibitors for the Treatment of Atopic Dermatitis. J Med Chem. 2025 Apr 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP14
Curated Selection
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