Ferroptosis inducer-7

Ferroptosis inducer-7 is an orally active and selective ferroptosis inducer via inositol 1,4,5-trisphosphate receptor (IP3R) /calcium release-activated calcium channel protein (ORAI) . Ferroptosis inducer-7 exhibits a notable effect in alleviating anemia symptoms, suppressing bone marrow CTLs activation, and improving hematopoietic function in immune-mediated bone marrow failure. Ferroptosis inducer-7 can be studied in research for aplastic anemia[1].

Product Specifications

CAS Number

[2723569-00-2]

UNSPSC

12352005

Target

ERK; Ferroptosis; MEK; p38 MAPK

Related Pathways

Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(/C=C/C1=CC=CC=C1)OC2=C3[C@]45[C@@](C=C(C(C5)=O)OC)([H])[C@](N(CC4)C)([H])CC3=C(C=C2OC)CO

Molecular Formula

C29H31NO6

Molecular Weight

489.56

References & Citations

[1]Zhang Z, et al., A Novel Compound 3a-M1, from Metabolites of Sinomenine Derivative 3a, Exerts Potent Anti-Aplastic Anemia Activity via IP3R/ORAI-Mediated CTL Ferroptosis. J Med Chem. 2025 Apr 17.