PSB-24000

PSB-24000 (Compound 27) is a selective ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 563 nM against human CD73 (Ki= 481 nM at membrane-bound CD73 in triple-negative breast cancer cells) . PSB-24000 interferes with CD73's recognition and action on the substrate AMP, and prevents the generation of immunosuppressive and cancer-promoting adenosine from AMP. PSB-24000 is promising for research of cancers[1].

Product Specifications

UNSPSC

12352005

Target

CD73

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=P(CP(O)(O)=O)(OCCCCCCN1C=NC2=C(N(CC3=CC=CC=C3)C)N=C(Cl)N=C12)O

Molecular Formula

C20H28ClN5O6P2

Molecular Weight

531.87

References & Citations

[1]Federico S, et al. Acyclic purine and pyrimidine nucleotide analogs as ecto-5’-nucleotidase (CD73) inhibitors[J]. European Journal of Medicinal Chemistry, 2025: 117653.