UNC9435
UNC9435 (compound 44) is a dual inhibitor of TYRO3/MERTK with IC50 values of 3.7 nM and 1.1 nM, respectively. UNC9435 reduces colony formation in non-small cell lung cancer cultures[1]
Product Specifications
UNSPSC
12352005
Target
TAM Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O[C@H]1CC[C@H](NC2=NC(NC3=CC=CC(Cl)=C3)=NC=C2C4CCN(CC5CCCC5)CC4)CC1
Molecular Formula
C27H38ClN5O
Molecular Weight
484.08
References & Citations
[1]Deyu Kong, et al. Discovery of Novel TYRO3/MERTK Dual Inhibitors. J Med Chem. 2025 Apr 24;68 (8) :8455-8470.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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