EGFR-IN-158
EGFR-IN-158 (compound 12e) is an orally active EGFR inhibitor with an IC50 of 0.22 nM for EGFR (Del19/T790M) . EGFR-IN-158 inhibits phosphorylation and downstream signaling by binding to EGFR, thereby inhibiting the proliferation of tumor cell lines and promoting apoptosis[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
C=CC(NC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(NCC)=O)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
Molecular Formula
C27H35ClN8O4S
Molecular Weight
603.14
References & Citations
[1]Yao H, et al. Synthesis and evaluation of novel amino pyrimidine derivatives containing sulfonamide and their application as EGFR inhibitors. Bioorg Chem. 2025 Jun 15;160:108467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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