Antibacterial agent 276

Antibacterial agent 276 (compound B3) is an antibacterial agent with EC50 values of 1.32 μg/mL and 2.80 μg/mL against Xanthomonas oryzae pv.oryzae and Xanthomonas axonopodis pv.citri, respectively. Antibacterial agent 276 disrupts the intracellular redox balance, and results in the accumulation of reactive oxygen species (ROS) and subsequent induction of apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bacterial; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(CCNCC1=CC=C(Cl)C=C1)N(CC2)C(C3=CC=C(OC(F)(F)F)C=C3)C4=C2C5=CC=CC=C5N4

Molecular Formula

C28H25ClF3N3O2

Molecular Weight

527.97

References & Citations

[1]Yang Y, et al. Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatment. Bioorg Chem. 2025 Jun 15;160:108473.