HDAC6-IN-56

HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6 with an IC50 of 1.3 nM. HDAC6-IN-56 suppresses S phase and induces apoptosis in HCT-116 colon cancer cells[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

ClC(SC=C1)=C1[C@H]2C3=C(C(C=CC=C4)=C4N3)C[C@@H]5N2C(CN(CCCCCCC(NO)=O)C5=O)=O

Molecular Formula

C25H27ClN4O4S

Molecular Weight

515.02

References & Citations

[1]Noreen Hemid, et al. Unlocking the potential of novel tetrahydro-β-carboline-based HDAC6 inhibitors for colorectal cancer therapy: Design, synthesis and biological evaluation. Bioorg Chem. 2025 Jun 15:160:108454.