FGFR4-IN-23

FGFR4-IN-23 (compound 48c) is a FGFR4 inhibitor with an IC50 value of 2.9 nM against FGFR4WT kinase. FGFR4-IN-23 inhibits the phosphorylation of FGFR4, AKT and MAPK[1].

Product Specifications

UNSPSC

12352101

Target

Akt; AMPK; FGFR

Related Pathways

Epigenetics; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(C1=C(NC(C=C)=O)C=C(N2CCN(C)CC2=O)C=C1F)NC3=NNC4=CC=C(O[C@H](C)C5=C(Cl)C=NC=C5Cl)C=C43

Molecular Formula

C29H26Cl2FN7O4

Molecular Weight

626.47

References & Citations

[1]Guo J, et al. Optimization of Aminoindazole derivatives as highly selective covalent inhibitors for wild-type and mutant FGFR4. Bioorg Chem. 2025 Jun 15;160:108469.