Anticancer agent 273

Anticancer agent 273 (Compound 9q) is a potent anticancer agent found in matrine. Anticancer agent 273 inhibits the proliferation of cancer cells (e.g., HeLa cells with an IC50 value of 4.48 μM) . Anticancer agent 273 exerts anticancer effects by modulating the expression of PI3K/AKT and activating transcription factor 4 (ATF4), which promotes endoplasmic reticulum stress and induces apoptosis. Anticancer agent 273 is promising for research of cancers, such as cervical cancer[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; PI3K

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

[H][C@@]12CCCN3CCC[C@@]([C@@]31[H])([C@]4(CC/C(C(N4C2)=O)=C\OC(C5=CN(C6=C5C=CC=C6)CC7=CC=CC=C7C#N)=O)[H])[H]

Molecular Formula

C33H34N4O3

Molecular Weight

534.65

References & Citations

[1]Wang X, et al. Design, synthesis and in vitro and in vivo biological evaluation of matrine derivatives as efficient anticancer agents with the characteristics of endoplasmic reticulum stress induction and apoptosis activation. Bioorg Chem. 2025 Apr 16;160:108482.