Aromatase-IN-5
Aromatase-IN-5 (Compound 10) is a potent inhibitor of aromatase with an IC50 value of 0.06 μM. Aromatase-IN-5 effectively blocks estrogen production. Aromatase-IN-5 inhibits the proliferation of breast cancer cell lines like MCF-7, arrests the cell cycle at the G1 phase, and induces apoptosis. Aromatase-IN-5 is promising for research of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Cytochrome P450
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=S(C(C=C1)=CC=C1N2C(NC(N)=S)=C(C#N)C(C3=CC=CC=C3)=C2)(NC4=NN=C(Cl)C=C4)=O
Molecular Formula
C22H16ClN7O2S2
Molecular Weight
509.99
References & Citations
[1]Zahran SS, et al. Novel chloropyridazine sulfonamides as aromatase inhibitors and apoptotic inducers in breast cancer. Bioorg Chem. 2025 Apr 15;160:108470.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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