Aromatase-IN-5

Aromatase-IN-5 (Compound 10) is a potent inhibitor of aromatase with an IC50 value of 0.06 μM. Aromatase-IN-5 effectively blocks estrogen production. Aromatase-IN-5 inhibits the proliferation of breast cancer cell lines like MCF-7, arrests the cell cycle at the G1 phase, and induces apoptosis. Aromatase-IN-5 is promising for research of breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Cytochrome P450

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=S(C(C=C1)=CC=C1N2C(NC(N)=S)=C(C#N)C(C3=CC=CC=C3)=C2)(NC4=NN=C(Cl)C=C4)=O

Molecular Formula

C22H16ClN7O2S2

Molecular Weight

509.99

References & Citations

[1]Zahran SS, et al. Novel chloropyridazine sulfonamides as aromatase inhibitors and apoptotic inducers in breast cancer. Bioorg Chem. 2025 Apr 15;160:108470.