HDAC6-IN-55
HDAC6-IN-55 (Compound 15B) is a potent HDAC6 inhibitor and an effective anti-inflammatory agent. HDAC6-IN-55 alleviates atopic dermatitis through anti-inflammatory effects facilitated via TLR4/MAPK, STAT3 and NF-κB pathways. HDAC6-IN-55 alleviates symptoms such as skin edema, dryness, crusting, and peeling in 2,4-dinitrochlorobenzene (DNCB) -induced atopic dermatitis mice[1].
Product Specifications
UNSPSC
12352211
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Inflammation/Immunology
Smiles
O=C(NO)CCCCCCNC1=NC=C(C2=CC=CC=C2)C(C3=CC=CC=C3)=N1
Molecular Formula
C23H26N4O2
Molecular Weight
390.48
References & Citations
[1]Chen JT, et, al. The diphenylpyrimidine derivative as a novel HDAC6 inhibitor alleviates atopic dermatitis through anti-inflammatory effects facilitated via TLR4/MAPK, STAT3 and NF-κB pathways. Bioorg Chem. 2025 Jun 15:160:108451.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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