HDAC6-IN-55

HDAC6-IN-55 (Compound 15B) is a potent HDAC6 inhibitor and an effective anti-inflammatory agent. HDAC6-IN-55 alleviates atopic dermatitis through anti-inflammatory effects facilitated via TLR4/MAPK, STAT3 and NF-κB pathways. HDAC6-IN-55 alleviates symptoms such as skin edema, dryness, crusting, and peeling in 2,4-dinitrochlorobenzene (DNCB) -induced atopic dermatitis mice[1].

Product Specifications

UNSPSC

12352211

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Inflammation/Immunology

Smiles

O=C(NO)CCCCCCNC1=NC=C(C2=CC=CC=C2)C(C3=CC=CC=C3)=N1

Molecular Formula

C23H26N4O2

Molecular Weight

390.48

References & Citations

[1]Chen JT, et, al. The diphenylpyrimidine derivative as a novel HDAC6 inhibitor alleviates atopic dermatitis through anti-inflammatory effects facilitated via TLR4/MAPK, STAT3 and NF-κB pathways. Bioorg Chem. 2025 Jun 15:160:108451.