EGFR-IN-161

EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of L858R/T790M/C797S mutant EGFR kinases, with an IC50 of 0.87 nM. EGFR-IN-161 can induce apoptosis process, G1-phase arrestation, and migration inhibition in tumor cells[1].

Product Specifications

CAS Number

[3031099-34-7]

UNSPSC

12352101

Target

Apoptosis; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

COC1=CC(N(CCN(C)C)C)=C(C=C1NC2=NC(C3=CN(C4=C3C=CC=C4)CCCO)=CC=N2)/N=C/C5=C(C(Cl)=NC=C5)Cl

Molecular Formula

C33H36Cl2N8O2

Molecular Weight

647.60

References & Citations

[1]Ding S, et, al. Design, synthesis and biological evaluation of imine-containing inhibitors against the triple-mutant EGFR kinases based on the scaffold of osimertinib. Bioorg Chem. 2025 Jun 15:160:108474.