SDH-IN-25

SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L) . SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43) . SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control[1].

Product Specifications

CAS Number

[3052432-15-9]

UNSPSC

12352101

Target

Fungal; MMP; Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

ClC1=CC(Cl)=C(OCC(NNC2=CC=C(Br)C=C2)=O)C(C3OC(C(C3)=C)=O)=C1

Molecular Formula

C19H15BrCl2N2O4

Molecular Weight

486.14

References & Citations

[1]Wang FY, Xu D, He HW, Lin GT, Zhou H, Liu X, Xu G. Discovery of α-Methylene-γ-Butyrolactone Derivatives with Hydrazide Moieties as Novel Fungicidal Agents. J Agric Food Chem. 2025 Apr 23;73 (16) :9521-9532.