TRPV1 antagonist 10
TRPV1 antagonist 10 is an orally active and potent TRPV1 antagonist (IC50 = 33.06 nM), moderate to weak URAT1 (IC50 = 22.51 μM) and GLUT9 (60.25% at 50 μM) inhibitor. TRPV1 antagonist 10 has analgesic and urate-lowering effect. TRPV1 antagonist 10 can be studied for research in hyperuricemia and inflammatory pain[1].
Product Specifications
CAS Number
896584-55-7
UNSPSC
12352211
Target
Cytochrome P450; GLUT; Interleukin Related; TNF Receptor; TRP Channel; URAT1
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Endocrinology; Inflammation/Immunology; Neurological Disease
Smiles
O=C(NC1=CC(OCCO2)=C2C=C1)NC3=CC=C(OCO4)C4=C3
Molecular Formula
C16H14N2O5
Molecular Weight
314.29
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1; CYP2; CYP3; TRPA1; TRPM8; TRPV1
Frequently Asked Questions
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