TRPV1 antagonist 10

TRPV1 antagonist 10 is an orally active and potent TRPV1 antagonist (IC50 = 33.06 nM), moderate to weak URAT1 (IC50 = 22.51 μM) and GLUT9 (60.25% at 50 μM) inhibitor. TRPV1 antagonist 10 has analgesic and urate-lowering effect. TRPV1 antagonist 10 can be studied for research in hyperuricemia and inflammatory pain[1].

Product Specifications

CAS Number

[896584-55-7]

UNSPSC

12352211

Target

Cytochrome P450; GLUT; Interleukin Related; TNF Receptor; TRP Channel; URAT1

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Endocrinology; Inflammation/Immunology; Neurological Disease

Smiles

O=C(NC1=CC(OCCO2)=C2C=C1)NC3=CC=C(OCO4)C4=C3

Molecular Formula

C16H14N2O5

Molecular Weight

314.29

References & Citations

[1]Chunxia Liu, et al., Structure Optimization of Natural Product Piperine to Obtain Novel and Potent Analogs with Anti-inflammation Pain and Urate-Lowering Effect, European Journal of Medicinal Chemistry, 2025, 117649, ISSN 0223-5234