Multi-target kinase inhibitor 4

Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and potent chemosensitizer that can increase the amount of DNA double strand breaks induced by Doxorubicin (HY-15142A) . Multi-target kinase inhibitor 4 is an efficient inhibitor of multidrug resistance (MDR) that exhibits inhibitory activity toward P-glycoprotein-mediated drug efflux. Multi-target kinase inhibitor 4 can be loaded into PEG-coated LNPs[1].

Product Specifications

UNSPSC

12352005

Target

DNA-PK; P-glycoprotein; PI3K

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(CN1CCCCC1)NC2=CC=C(C3=C4C(C(NC(N5CCOCC5)=N4)=O)=CC=C3)C=N2

Molecular Formula

C24H28N6O3

Molecular Weight

448.52

References & Citations

[1]Sukupova M, et, al. N- (5- (2-morpholino-4-oxo-3,4-dihydroquinazolin-8-yl) pyridin-2-yl) acylamides as novel multi-PI3K/DNA-PK/P-gp inhibitors for efficient chemosensitization and MDR alleviation. Eur J Med Chem. 2025 Apr 15:292:117641.