KMG-1068
KMG-1068 (Compound 4a), a molecular glue, is a GSPT1/2 degrader. KMG-1068 effectively induces the CRBN-dependent degradation of GSPT1/2 by binding to the IMiD binding site on CRBN, facilitating the formation of a ternary complex with GSPT1/2. KMG-1068 is promising for research of cancers[1].
Product Specifications
UNSPSC
12352211
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C1C(C)=C(C)N=CN1CC(NC2=NC(C(OC)=O)=C(CCC3=CC=CC=C3)S2)=O
Molecular Formula
C21H22N4O4S
Molecular Weight
426.49
References & Citations
[1]Park S, et al. Discovery of a novel molecular glue degrader targeting GSPT1/2 with a non-IMiD-based CRBN binder. Eur J Med Chem. 2025 Apr 15;291:117642.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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