STAT3-D11-PROTAC-VHL
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting Signal Transducer and Activator of Transcription 3 (STAT3) . STAT3-D11-PROTAC-VHL exhibits anti-tumor activity with IC50 values of 1335 nM and 1973 nM against HeLa and MCF-7 cells, respectively. STAT3-D11-PROTAC-VHL binds to the DNA-binding domain of STAT3 and recruits the E3 ligase VHL to form a ternary complex, leading to the ubiquitination of STAT3 and subsequent degradation by the proteasome. STAT3-D11-PROTAC-VHL also inhibits tumor cell growth, induces cell cycle arrest and apoptosis, and suppresses tumor immune evasion[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; PROTACs; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
96.33
Smiles
[STAT3-D11-PROTAC-VHL]
References & Citations
[1]Li S, et al. Decoy-PROTAC for specific degradation of "Undruggable" STAT3 transcription factor. Cell Death Dis. 2025 Mar 21;16 (1) :197.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172767/STAT3-D11-PROTAC-VHL-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
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