PKMYT1-IN-9
PKMYT1-IN-9 is a highly selective and orally active PKMYT1 inhibitor (IC50: 4.4 nM) . PKMYT1-IN-9 shows more selective for PKMYT1 than WEE1 (IC50: 32.4 μM) . PKMYT1-IN-9 exhibits antitumor activity[1].
Product Specifications
CAS Number
3055031-36-9
UNSPSC
12352005
Target
Wee1
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1NC2=C(C)C(C)=CN=C2C(C3=CC=C(C4=C3C=NN4)F)=C1N
Molecular Formula
C17H14FN5O
Molecular Weight
323.32
References & Citations
[1]Chen B, et al. Discovery of Naphthyridinone Derivatives as Selective and Potent PKMYT1 Inhibitors with Antitumor Efficacy. J Med Chem. 2025 Apr 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKMYT1
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