FG-2101

FG-2101 is a selective and orally active non-hydroxamate LpxC inhibitor with an IC50 of ~1 nM. FG-2101 exhibits exquisite selectivity over other bacterial and human metalloenzymes. FG-2101 can be used for the study of Gram-negative bacteria infections including drug-resistant strains[1].

Product Specifications

CAS Number

[2919723-66-1]

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

N#CC1CN(C1)C[C@H](C2=CC=C(C=C2)C#CC3=CC=C(C=C3)CN4CCOCC4)CC5=C(C(NC=N5)=O)OP(O)(O)=O

Molecular Formula

C30H32N5O6P

Molecular Weight

589.58

References & Citations

[1]4185279-First disclosure of FG-2101: A novel non-hydroxamate inhibitor of LpxC for treating Gram-negative bacteria infections including drug-resistant strains.