PRMT5-MTA-IN-3-d3
PRMT5-MTA-IN-3-d3 (compound P22) is the deuterium labeled PRMT5-MTA-IN-3 (HY-172733) . PRMT5-MTA-IN-3-d3 is an orally active PRMT5-MTA inhibitor. PRMT5-MTA-IN-3-d3 has antiproliferative effects on HTC116-MTAP del and wild type colorectal cancer HCT-116 cell lines, with IC50 values of 6 nM and 961 nM, respectively. PRMT5-MTA-IN-3-d3 has anticancer effects, especially for MTAP-deficient tumors, such as non-small cell lung cancer (NSCLC), pancreatic cancer[1].
Product Specifications
CAS Number
[3052146-54-7]
UNSPSC
12352211
Target
Histone Methyltransferase; Isotope-Labeled Compounds
Related Pathways
Epigenetics; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CN1N=CC2=C1C(N)=NC=C2NC(C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C([2H])([2H])[2H])=O)=O
Molecular Formula
C19H14D3F3N6O3
Molecular Weight
437.39
References & Citations
[1]Bing Liu, et al. Inhibiteur de prmt5-mta. WO2024152973A1.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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