8-Oxo-dATP (lithium)

8-Oxo-dATP lithium, as an oxidized purine nucleoside triphosphate, is hydrolyzed by MTH1 into monophosphates, thereby preventing errors caused by its misincorporation during DNA replication or transcription[1].

Product Specifications

CAS Number

[3056945-23-1]

UNSPSC

12352005

Target

Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O[C@H]1C[C@H](N(C2=NC=NC(N)=C2N3)C3=O)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O

Molecular Formula

C10H12Li4N5O13P3

Molecular Weight

530.91

References & Citations

[1]Yasunari Sakai, et al. A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J Biol Chem. 2002 Mar 8;277 (10) :8579-87.