8-Oxo-dATP (lithium)
8-Oxo-dATP lithium, as an oxidized purine nucleoside triphosphate, is hydrolyzed by MTH1 into monophosphates, thereby preventing errors caused by its misincorporation during DNA replication or transcription[1].
Product Specifications
CAS Number
3056945-23-1
UNSPSC
12352005
Target
Endogenous Metabolite; Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O[C@H]1C[C@H](N(C2=NC=NC(N)=C2N3)C3=O)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
Molecular Formula
C10H12Li4N5O13P3
Molecular Weight
530.91
References & Citations
[1]Yasunari Sakai, et al. A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J Biol Chem. 2002 Mar 8;277 (10) :8579-87.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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