IIP0943
IIP0943 is a selective inhibitor of PLK1 (polo-like kinase 1), with an IC50 of 5.1 nM for PLK1. In addition, IIP0943 exhibits antiproliferative activity against HCT116 cells, with an IC50 of 0.22 µM. These results suggest that IIP0943 holds promise for research in the field of cancer therapeutics[1].
Product Specifications
CAS Number
3040106-93-9
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CN1CCN(C2=CC(NC3=NC=C(C)C(OC4=CC=CC5=C4SC(C(N)=O)=C5)=N3)=C(OC)C=C2)CC1
Molecular Formula
C26H28N6O3S
Molecular Weight
504.60
References & Citations
[1]Xie W, et al. Accelerating discovery of bioactive ligands with pharmacophore-informed generative models. Nat Commun. 2025 Mar 10;16 (1) :2391.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1
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