GW461484A
GW461484A is a small-molecule inhibitor targeting Candida albicans Yck2, with an IC50 of 0.11 µM. It exhibits antifungal activity against C. albicans with a MIC80 of 12.5 µM. GW461484A holds potential for research on fungal diseases, such as drug-resistant Candida infections[1].
Product Specifications
CAS Number
401815-65-4
UNSPSC
12352101
Target
Casein Kinase; Fungal
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Stem Cell/Wnt
Field of Research
Infection
Smiles
FC(C=C1)=CC=C1C2=NN3C(C=CC(C)=C3)=C2C4=CC=NC=C4
Molecular Formula
C19H14FN3
Molecular Weight
303.33
References & Citations
[1]Puumala E, et al. Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nat Commun. 2025 Mar 4;16 (1) :2156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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