HPK1-IN-59
HPK1-IN-59 (compound 39) is an orally active HPK1 inhibitor with an IC50 of 0.70 nM. HPK1-IN-59 has favorable oral bioavailability in mice[1].
Product Specifications
UNSPSC
12352005
Target
MAP4K
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C)(C1=CC(C2=CN(N=C2)CC(C)(O)C)=CC3=CN=C(N=C31)NC4=CC(C(C)(O5)C)=C(C=C4)C5=O)O
Molecular Formula
C28H31N5O4
Molecular Weight
501.58
References & Citations
[1]Wan B, et al. Structure-Guided Optimization of 2-Aminoquinazoline Hematopoietic Progenitor Kinase 1 Inhibitors for Improved Oral Bioavailability and Synergistic Antitumor Immunity. J Med Chem. 2025 May 22;68 (10) :10439-10460.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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